To be the best doctor you can be, you need the best information. For more than 90 years, what is now called Goldman-Cecil Medicine has been the authoritative source for internal medicine and the care of adult patients. Every chapter is written by acclaimed experts who, with the oversight of our editors, provide definitive, unbiased advice on the diagnosis and treatment of thousands of common and uncommon conditions, always guided by an understanding of the epidemiology and pathobiology, as well as the latest medical literature.
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Key Features
- More than 400 chapters authored by a veritable "Who’s Who" of modern medicine
- A practical, templated organization with an emphasis on evidence-based references
- Thousands of algorithms, figures, and tables that make its information readily accessible
- Supplemented by over 1500 board-style questions and answers to help you prepare for certification and recertification examinations
Author Information
By Lee Goldman, MD, Professor of Medicine and Epidemiology Dean Emeritus of the Faculties of Health Sciences and Medicine Columbia University Medical Center, New York and Andrew I. Schafer, MD, Professor of Medicine, Director, Richard T. Silver Center for Myeloproliferative Neoplasms, Weill Cornell Medical College, New York, New York
SECTION 1: SOCIAL AND ETHICAL ISSUES IN MEDICINE
1. Approach to Medicine, the Patient, and the Medical Profession: Medicine as a Learned and Humane Profession
2. Bioethics in the Practice of Medicine
3. Care of Dying Patients and Their Families
4. Cultural and Social Disparities in Health Care
5. Global Health
SECTION 2: PRINCIPLES OF EVALUATION AND MANAGEMENT
6. Approach to the Patient: History and Physical Examination
7. Approach to the Patient with Abnormal Vital Signs
8. Statistical Interpretation of Data and Using Data for Clinical Decisions
9. Measuring Health and Health Care
10. Quality of Care and Patient Safety
11. Comprehensive Chronic Disease Management
SECTION 3: PREVENTIVE AND ENVIRONMENTAL ISSUES
12. The Periodic Health Examination
13. Physical Activity
14. Adolescent Medicine
15. Immunization
16. Principles of Occupational and Environmental Medicine
17. Radiation Injury
18. Bioterrorism
19. Chronic Poisoning: Trace Metals and Others
SECTION 4: AGING AND GERIATRIC MEDICINE
20. Epidemiology of Aging: Implications of the Aging of Society
21. Geriatric Assessment
22. Common Clinical Sequelae of Aging
23. Urinary Incontinence
24. Neuropsychiatric Aspects of Aging
25. Delirium in the Older Patient
SECTION 5: CLINICAL PHARMACOLOGY
26. Principles of Drug Therapy
27. Pain
28. Biology of Addiction
29. Nicotine and Tobacco
30. Alcohol Use Disorders
31. Drugs of Abuse
32. Synthetic Immunomodulatory Drug Including Glucocorticoids
33. Biologic Agents and Signaling Inhibitors
34. Complementary, Alternative, and Integrative Medicine
SECTION 6: GENETICS
35. Principles of Genetics
36. Clinical Genomics – Genome Structure and Variation
37. Applications of Molecular Technologies to Clinical Medicine
38. Regenerative Medicine, Cell, and Gene Therapies
SECTION 7: PRINCIPLES OF IMMUNOLOGY AND INFLAMMATION
39. The Innate Immune System
40. The Adaptive Immunse System
41. Mechanisms of Immune-Mediated Tissue Injury
42. Mechanisms of Inflammation and Tissue Repair
43. Transplantation Immunology
44. Complement System in Disease
SECTION 8: CARDIOVASCULAR DISEASE
45. Approach to the Patient with Possible Cardiovascular Disease
46. Epidemiology of Cardiovascular Disease
47. Cardiac and Circulatory Function
48. Electrocardiography
49. Echocardiography
50. Noninvasive Cardiac Imaging
51. Catheterization and Angiography
52. Heart Failure: Pathophysiology and Diagnosis
53. Heart Failure: Management and Prognosis
54. Diseases of the Myocardium and Endocardium
55. Principles of Electrophysiology
56. Approach to the Patient with Suspected Arrhythmia
57. Approach to Cardiac Arrest and Life-Threatening Arrhythmias
58. Cardiac Arrhythmias with Supraventricular Origin
59. Ventricular Arrhythmias
60. Electrophysiologic Interventional Procedures and Surgery
61. Congenital Heart Disease in Adults
62. Angina Pectoris and Stable Ischemic Heart Disease
63. Acute Coronary Syndrome: Unstable Angina and Non-ST Elevation Myocardial Infarction
64. ST Elevation Acute Myocardial Infarction and Complications of Myocardial Infarction
65. Interventional and Surgical Treatment of Coronary Artery Disease
66. Valvular Heart Disease
67. Infective Endocarditis
68. Pericardial Diseases
69. Diseases of the Aorta
SECTION 9: VASCULAR MEDICINE
70. Arterial Hypertension
71. Atherosclerotic Peripheral Arterial Disease
72. Other Peripheral Arterial Diseases
73. Thrombotic Disorders: Hypercoagulable States
74. Venous Thrombosis and Embolism
75. Pulmonary Hypertension
76. Antithrombotic and Antiplatelet Therapy
SECTION 10: RESPIRATORY DISEASES
77. Approach to the Patient with Respiratory Disease
78. Imaging in Pulmonary Disease
79. Respiratory Function and Testing
80. Disorders of Ventilatory Control
81. Asthma
82. Chronic Obstructive Pulmonary Disease
83. Cystic Fibrosis
84. Bronchiectasis, Atelectasis, Cysts, and Localized Lung Disorders
85. Alveolar Filling Disorders
86. Interstitial Lung Disease
87. Occupational Lung Disease
88. Physical and Chemical Injuries of the Lung
89. Sarcoidosis
90. Acute Bronchitis and Tracheitis
91. Overview of Pneumonia
92. Diseases of the Diaphragm, Chest Wall, Pleura, and Mediastinum
93. Interventional and Surgical Approaches to Lung Disease
SECTION 11: CRITICAL CARE MEDICINE
94. Approach to the Patient in a Critical Care Setting
95. Respiratory Monitoring in Critical Care
96. Acute Respiratory Failure
97. Mechanical Ventilation
98. Approach to the Patient with Shock
99. Cardiogenic Shock
100. Shock Syndromes Related to Sepsis
101. Disorders Due to Heat and Cold
102. Acute Poisoning
103. Medical Aspects of Trauma and Burns
104. Envenomation, Bites, and Stings
105. Rhabdomyolysis
SECTION 12: RENAL AND GENITOURINARY DISEASES
106. Approach to the Patient with Renal Disease
107. Structure and Function of the Kidneys
108. Disorders of Sodium and Water Homeostasis
109. Potassium Disorders
110. Acid-Base Disorders
111. Disorders of Magnesium and Phosphorus
112. Acute Kidney Injury
113. Glomerular Disorders and Nephrotic Syndromes
114. Tubulointerstitial Diseases
115. Diabetes and the Kidney
116. Vascular Disorders of the Kidney
117. Nephrolithiasis
118. Cystic Kidney Diseases
119. Hereditary Nephropathies and Developmental Abnormalities of the Urinary Tract
120. Benign Prostatic Hyperplasia and Prostatitis
121. Chronic Kidney Disease
122. Treatment of Irreversible Renal Failure
SECTION 13: GASTROINTESTINAL DISEASES
123. Approach to the Patient with Gastrointestinal Disease
124. Diagnostic Imaging Procedures in Gastroenterology
125. Gastrointestinal Endoscopy
126. Gastrointestinal Hemorrhage
127. Disorders of Gastrointestinal Motility
128. Functional Gastrointestinal Disorders: Irritable Bowel Syndrome, Dyspepsia, Esophageal Chest Pain, and Heartburn
129. Diseases of the Esophagus
130. Acid Peptic Disease
131. Approach to the Patient with Diarrhea and Malabsorption
132. Inflammatory Bowel Disease
133. Inflammatory and Anatomic Diseases of the Intestine, Peritoneum, Mesentery, and Omentum
134. Vascular Diseases of the Gastrointestinal Tract
135. Pancreatitis
136. Diseases of the Rectum and Anus
SECTION 14: DISEASES OF THE LIVER, GALLBLADDER, AND BILE DUCTS
137. Approach to the Patient with Liver Disease
138. Approach to the Patient with Jaundice or Abnormal Liver Tests
139. Acute Viral Hepatitis
140. Chronic Viral and Autoimmune Hepatitis
141. Toxin- and Drug-Induced Liver Disease
142. Bacterial, Parasitic, Fungal, and Granulomatous Liver Diseases
143. Alcoholic and Nonalcoholic Steatohepatitis
144. Cirrhosis and Its Sequelae
145. Hepatic Failure and Liver Transplantation
146. Diseases of the Gallbladder and Bile Ducts
SECTION 15: HEMATOLOGIC DISEASES
147. Hematopoiesis and Hematopoietic Growth Factors
148. The Peripheral Blood Smear
149. Approach to the Anemias
150. Microcytic and Hypochromic Anemias
151. Autoimmune and Intravascular Hemolytic Anemias
152. Hemolytic Anemias: Red Cell Membrane and Metabolic Defects
153. The Thalassemias
154. Sickle Cell Disease and Other Hemoglobinopathies
155. Megaloblastic Anemias
156. Aplastic Anemia and Related Bone Marrow Failure States
157. Polycythemia Vera, Essential Thrombocythemia, and Primary Myelobfibrosis
158. Leukocytosis and Leukopenia
159. Approach to the Patient with Lymphadenopathy and Splenomegaly
160. Histiocytoses
161. Eosinophilic Syndromes
162. Approach to the Patient with Bleeding and Thrombosis
163. Thrombocytopenia
164. Von Willebrand Disease and Hemorrhagic Abnormalities of Platelet and Vascular Function
165. Hemorrhagic Disorders: Coagulation Factor Deficiencies
166. Hemorrhagic Disorders: Disseminated Intravascular Coagulation, Liver Failure, and Vitamin K Deficiency
167. Transfusion Medicine
168. Hematopoietic Stem Cell Transplantation
SECTION 16: ONCOLOGY
169. Approach to the Patient with Cancer
170. Epidemiology of Cancer
171. Cancer Biology and Genetics
172. Myelodysplastic Syndromes
173. The Acute Leukemias
174. The Chronic Lymphocytic Leukemia
175. Chronic Myeloid Leukemias
176. Non-Hodgkin Lymphomas
177. Hodgkin Lymphoma
178. Plasma Cell Disorders
179. Amyloidosis
180. Tumors of the Central Nervous System
181. Head and Neck Cancer
182. Lung Cancer and Other Pulmonary Neoplasms
183. Neoplasms of the Esophagus and Stomach
184. Neoplasms of the Small and Large Intestine
185. Pancreatic Cancer
186. Liver and Biliary Tract Tumors
187. Tumors of the Kidney, Bladder, Ureters, and Renal Pelvis
188. Breast Cancer and Benign Breast Disorders
189. Gynecologic Cancers
190. Testicular Cancer
191. Prostate Cancer
192. Malignant Tumors of Bone, Sarcomas, and Other Soft Tissue Neoplasms
193. Melanoma and Nonmelanoma Skin Cancers
SECTION 17: METABOLIC DISEASES
194. Approach to Inborn Errors of Metabolism
195. Disorders of Lipid Metabolism
196. Glycogen Storage Diseases
197. Lysosomal Storage Diseases
198. Homocystinuria and Hyperhomocysteinemia
199. The Porphyrias
200. Wilson’s Disease
201. Iron Overload (Hemochromatosis)
SECTION 18: NUTRITIONAL DISEASES
202. Nutrition’s Interface with Health and Disease
203. Protein-Energy Malnutrition
204. Nutrition in Hospitalized Patients
205. Vitamins, Trace Minerals, and Other Micronutrients
206. Eating Disorders
207. Obesity
SECTION 19: ENDOCRINE DISEASES
208. Approach to the Patient with Endocrine Disease
209. Principles of Endocrinology
210. Neuroendocrinology and the Neuroendocrine System
211. Anterior Pituitary
212. Posterior Pituitary
213. Thyroid
214. Adrenal Cortex
215. Adrenal Medulla, Catecholamines, and Pheochromocytoma
216. Diabetes Mellitus
217. Hypoglycemia/Pancreatic Islet Cell Disorders
218. Polyglandular Disorders
219. Neuroendocrine Tumors
220. Sexual Development and Identity
221. The Testis and Male Hypogonadism, Infertility, and Sexual Function
222. Ovaries and Pubertal Development
223. Reproductive Endocrinology and Infertility
SECTION 20: WOMEN'S HEALTH
224. Approach to Women’s Health
225. Contraception
226. Common Medical Problems in Pregnancy
227. Menopause
228. Intimate Partner Violence
SECTION 21: DISEASES OF BONE AND MINERAL METABOLISM
229. Approach to the Patient with Metabolic Bone Disease
230. Osteoporosis
231. Osteomalacia and Rickets
232. The Parathyroid Glands, Hypercalcemia, and Hypocalcemia
233. Paget’s Disease of Bone
234. Osteonecrosis, Osteosclerosis/Hyperostosis, and Other Disorders of Bone
SECTION 22: DISEASES OF ALLERGY AND CLINICAL IMMUNOLOGY
235. Approach to the Patient with Allergic or Immunologic Disease
236. Primary Immunodeficiency Diseases
237. Urticaria and Angioedema
238. Systemic Anaphylaxis, Food Allergy, and Insect Sting Allergy
239. Drug Allergy
240. Mastocytosis
SECTION 23: RHEUMATIC DISEASES
241. Approach to the Patient with Rheumatic Disease
242. Laboratory Testing in the Rheumatic Diseases
243. Imaging Studies in the Rheumatic Diseases
244. Inherited Diseases of Connective Tissue
245. The Systemic Autoinflammatory Diseases
246. Osteoarthritis
247. Bursitis, Tendinitis, and Other Periarticular Disorders and Sports Medicine
248. Rheumatoid Arthritis
249. The Spondyloarthropathies
250. Systemic Lupus Erythematosus
251. Systemic Sclerosis (Scleroderma)
252. Sjögren’s Syndrome
253. Inflammatory Myopathies
254. The Systemic Vasculitides
255. Giant Cell Arteritis and Polymyalgia Rheumatica
256. Infections of Bursae, Joints, and Bones
257. Crystal Deposition Diseases
258. Fibromyalgia, Chronic Fatigue Syndrome, and Myofascial Pain
259. Systemic Diseases in Which Arthritis Is a Feature
260. Surgical Treatment of Joint Diseases
SECTION 24: INFECTIOUS DISEASES
261. Introduction to Microbial Disease: Pathophysiology and Diagnostics
262. The Human Microbiome
263. Principles of Anti-Infective Therapy
264. Approach to Fever or Suspected Infection in the Normal Host
265. Approach to Fever and Suspected Infection in the Compromised Host
266. Prevention and Control of Health Care–Associated Infections
267. Approach to the Patient with Suspected Enteric Infection
268. Approach to the Patient with Urinary Tract Infection
269. Approach to the Patient with a Sexually Transmitted Infection
270. Approach to the Patient before and after Travel
271. Antibacterial Chemotherapy
272. Staphylococcal Infections
273. Streptococcus Pneumoniae Infections
274. Nonpneumococcal Streptococcal Infections and Rheumatic Fever
275. Enterococcal Infections
276. Diphtheria and Other Corynebacteria Infections
277. Listeriosis
278. Anthrax
279. Erysipelothrix Infections
280. Clostridial Infections
281. Diseases Caused by Non–Spore-Forming Anaerobic Bacteria
282. Neisseria Meningitidis Infections
283. Neisseria Gonorrhoeae Infections
284. Haemophilus and Moraxella Infections
285. Chancroid
286. Cholera and Other Vibrio Infections
287. Campylobacter Infections
288. Escherichia Coli Enteric Infections
289. Infections due to Other Members of the Enterobacteriaceae, including Management of Multidrug Resistant Strains
290. Pseudomonas and Related Gram-Negative Bacillary Infections
291. Diseases Caused by Acinetobacter and Stenotrophomonas Species
292. Salmonella Infections (including Typhoid Fever)
293. Shigellosis
294. Brucellosis
295. Tularemia and Other Francisella Infections
296. Plague and Other Yersinia Infections
297. Whooping Cough and Other Bordetella Infections
298. Legionella Infections
299. Bartonella Infections
300. Granuloma Inguinale (Donovanosis)
301. Mycoplasma Infections
302. Diseases Caused by Chlamydiae
303. Syphilis
304. Nonsyphilitic Treponematoses
305. Lyme Disease
306. Relapsing Fever and Other Borrelia Infections
307. Leptospirosis
308. Tuberculosis
309. The Nontuberculous Mycobacteria
310. Leprosy (Hansen Disease)
311. Rickettsial Infections
312. Zoonoses
313. Actinomycosis
314. Nocardiosis
315. Systemic Antifungal Agents
316. Endemic Mycoses
317. Cryptococcosis
318. Candidiasis
319. Aspergillosis
320. Mucormycosis
321. Pneumocystis Pneumonia
322. Mycetoma and Dematiaceous Fungal Infections
323. Antiparasitic Therapy
324. Malaria
325. African Sleeping Sickness
326. Chagas Disease
327. Leishmaniasis
328. Toxoplasmosis
329. Cryptosporidiosis
330. Giardiasis
331. Amebiasis
332. Babesiosis and Other Protozoan Diseases
333. Cestodes
334. Trematode Infections
335. Nematode Infections
336. Antiviral Therapy (Non-HIV)
337. The Common Cold
338. Respiratory Syncytial Virus
339. Parainfluenza Viral Disease
340. Influenza
341. Adenovirus Diseases
342. Coronaviruses
343. Measles
344. Rubella (German Measles)
345. Mumps
346. Cytomegalovirus, Epstein-Barr Virus, and Slow Virus Infections of the Central Nervous System
347. Parvovirus
348. Smallpox, Monkeypox, and Other Poxvirus Infections
349. Papillomavirus
350. Herpes Simplex Virus Infections
351. Varicella-Zoster Virus (Chickenpox, Shingles)
352. Cytomegalovirus
353. Epstein-Barr Virus Infection
354. Retroviruses Other Than Human Immunodeficiency Virus
355. Enteroviruses
356. Rotaviruses, Noroviruses, and Other Gastrointestinal Viruses
357. Viral Hemorrhagic Fevers
358. Arboviruses Causing Fever and Rash Syndromes
359. Arboviruses Affecting the Central Nervous System
SECTION 25: HIV AND THE ACQUIRED IMMUNODEFICIENCY SYNDROME
360. Epidemiology of Human Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome
361. Immunopathogenesis of Human Immunodeficiency Virus Infection
362. Biology of Human Immunodeficiency Viruses
363. Prevention of Human Immunodeficiency Virus Infection
364. Antiretroviral Therapy of HIV/AIDS
365. MICROBIAL COMPLICATIONS IN PERSONS INFECTED WITH HUMAN IMMUNODEFICIENCY VIRUS
366. Systemic Manifestations of HIV/AIDS
367. Immune Reconstitution Inflammatory Syndrome in HIV/AIDS
SECTION 26: NEUROLOGY
368. Approach to the Patient with Neurologic Disease
369. Psychiatric Disorders in Medical Practice
370. Headaches and Other Head Pain
371. Traumatic Brain Injury and Spinal Cord Injury
372. Mechanical and Other Lesions of the Spine, Nerve Roots, and Spinal Cord
373. Regional Cerebral Dysfunction: Higher Mental Functions
374. Cognitive Impairment and Dementia
375. The Epilepsies
376. Coma, Vegetative State, and Brain Death
377. Sleep Disorders
378. Approach to Cerebrovascular Diseases
379. Ischemic Cerebrovascular Disease
380. Hemorrhagic Cerebrovascular Disease
381. Parkinsonism
382. Other Movement Disorders
383. Multiple Sclerosis and Demyelinating Conditions of the Central Nervous System
384. Meningitis: Bacterial, Viral, and Other
385. Brain Abscess and Parameningeal Infections
386. Acute Viral Encephalitis
387. Prion Diseases
388. Nutritional and Alcohol-Related Neurologic Disorders
389. Congenital, Developmental, and Neurocutaneous Disorders
390. Autonomic Disorders and Their Management
391. Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases
392. Peripheral Neuropathies
393. Muscle Diseases
394. Disorders of Neuromuscular Transmission
SECTION 27: EYE, EAR, NOSE, AND THROAT DISEASES
395. Diseases of the Visual System
396. Neuro-Ophthalmology
397. Diseases of the Mouth and Salivary Glands
398. Approach to the Patient with Nose, Sinus, and Ear Disorders
399. Smell and Taste
400. Hearing and Equilibrium
401. Throat Disorders
SECTION 28: MEDICAL CONSULTATION
402. Principles of Medical Consultation
403. Preoperative Evaluation
404. Overview of Anesthesia
405. Postoperative Care and Complications
406. Medical Consultation in Psychiatry
SECTION 29: SKIN DISEASES
407. Approach to Skin Diseases
408. Principles of Therapy of Skin Diseases
409. Eczema, Photodermatoses, Papulosquamous (including Fungal) Diseases, and Figurate Erythemas
410. Macular, Papular, Vesiculobullous, and Pustular Diseases
411. Urticaria, Drug Hypersensitivity Rashes, Nodules and Tumors, and Atrophic Diseases
412. Infections, Hyperpigmentation and Hypopigmentation, Regional Dermatology, and Distinctive Lesions in Black Skin
413. Diseases of Hair and Nails
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