Preface vii
List of Contributors ix
SECTION 1
Components of the Immune System 1
1 Introduction to the Immune System 3
David Male
2 Cells, Tissues, and Organs of the
Immune System 17
Peter M Lydyard and Nino Porakishvili
3 Antibodies 51
Roy Jefferis
4 Complement 71
B Paul Morgan
5 T Cell Receptors and MHC Molecules 89
David B Roth
SECTION 2
Modes of Immune Response 107
6 Mechanisms of Innate Immunity 109
David Male
7 Mononuclear Phagocytes in Immune
Defense 125
Luisa Martinez-Pomares and
Siamon Gordon
8 Antigen Presentation 143
David Male
9 Cell Cooperation in the Antibody
Response 157
Joseph C Marini and Kalpit A Vora
10 Cell-mediated Cytotoxicity 171
Victoria Male
11 Regulation of the Immune Response 183
David Bending
12 Immune Responses in Tissues 199
David Male
SECTION 3
Defense Against Infectious Agents 209
13 Immunity to Viruses 211
Persephone Borrow and Anthony A Nash
14 Immunity to Bacteria and Fungi 223
Gregory J Bancroft
15 Immunity to Protozoa and Worms 243
Richard J Pleass
16 Primary Immunodeficiencies 263
Luigi D Notarangelo
17 AIDS, Secondary Immunodeficiency
and Immunosuppression 277
Dean H Kedes and Lisa A Nichols
18 Vaccination 289
Colin Casimir
SECTION 4
Immune Responses Against Tissues 305
19 Immunological Tolerance 307
Thomas Kamradt
20 Autoimmunity and Autoimmune
Disease 323
James E Peters and David A Isenberg
21 Transplantation and Rejection 341
Andrew J T George
22 Immunity to Cancers 355
Pramod K Srivastava
V
SECTION 5
Hypersensitivity 369
23 Immediate Hypersensitivity (Type I) 371
Thomas A E Platts-Mills
24 Hypersensitivity (Type II) 393
David Male
25 Hypersensitivity (Type III) 405
David P D’Cruz
26 Hypersensitivity (Type IV) 419
Warwick J Britton
Appendices online
1. Major Histocompatibility Complex
2. CD System
3. The Major Cytokines
4. Human Chemokines and Their Receptors
Critical thinking: Explanations 433
Glossary 445
Index 455
vi
Contents