Written by carefully selected global experts, practicing physicians, and educators in the various sub-disciplines of biochemistry, Medical Biochemistry, 6th Edition, offers a unique combination of research and clinical practice tailored to today's integrated courses. Covering clinically relevant topics in greater detail than other texts, this outstanding resource provides a strong overview of traditional areas in medical biochemistry along with state-of-the-art coverage of today’s latest developments. You’ll learn basic science concepts alongside clinical cases that describe patients likely to be encountered in clinical training, as well as how to use laboratory tests to diagnose and monitor the most important conditions. Thorough yet accessible, this clinically focused text is useful from medical school to clinical practice.
Key Features
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Features a strong clinical orientation, emphasizing the relevance of biochemistry to the daily practice of medicine.
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Highlights the latest developments in regulatory and molecular biology, signal transduction, age-related chronic disease, epigenetics, and bioinformatics and the “-omics, as well as important global medical issues such as diabetes mellitus, obesity and malnutrition, cancer and atherosclerotic cardiovascular disease, and nutrition and exercise.
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Emphasizes clinical evaluation, maintenance of good health, and disease prevention, as well as translational medicine and the diagnosis and treatment of disease.
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Contains organ-focused chapters addressing the biochemistry of the bone, kidney, liver, lungs and muscle; and system-focused chapters on the biochemistry of the immune and endocrine systems, neurochemistry and neurotransmission, and cancer.
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Includes clear, colorful icons and illustrations that help you easily navigate the text and understand the material.
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Provides online features such as challenging “Active Learning questions for independent study, relevant websites that reinforce or supplement chapter content, 150+ multiple-choice and USMLE-style questions, a quick-reference glossary, additional images and case studies, references to current literature, and more.
Author Information
Edited by John W Baynes, PhD, Carolina Distinguished Professor Emeritus; Department of Pharmacology, Physiology and Neuroscience; University of South Carolina School of Medicine; Columbia, South Carolina; Marek H. Dominiczak, Dr, Hab, Med, FRCPath, Honorary Professor of Clinical Biochemistry and Medical Humanities, University of Glasgow and Consultant Biochemist, NHS Greater Glasgow and Clyde, Glasgow, UK
SECTION 1 Introduction
1 Biochemistry and Clinical Medicine: Introduction and Overview
SECTION 2 Molecules and Cells
2 Amino Acids and Proteins
3 Carbohydrates and Lipids
4 Membranes and Transport
SECTION 3 Metabolism
5 Oxygen Transport
6 Catalytic Proteins - Enzymes
7 Vitamins and Minerals
8 Bioenergetics and Oxidative Metabolism
9 Glycolysis and the Pentose Phosphate Pathway
10 The Tricarboxylic Acid Cycle
11 Fatty Acid and Triglyceride Catabolism
12 Biosynthesis and Storage of Carbohydrate
13 Biosynthesis and Storage of Fatty Acids
14 Biosynthesis of Cholesterol and Steroids
15 Biosynthesis and Degradation of Amino Acids
16 Biosynthesis and Degradation of Nucleotides
17 Complex Carbohydrates: Glycoproteins
18 Complex Lipids
19 The Extracellular Matrix
SECTION 4 Molecular Basis of Inheritance
20 Deoxyribonucleic Acid
21 Ribonucleic Acid
22 Protein Synthesis and Turnover
23 Regulation of Gene Expression: Basic Mechanisms
24 Genomics, Proteomics and Metabolomics
SECTION 5 Signalling and Growth
25 Membrane Receptors and Signal Transduction
26 Neurotransmitters
27 Biochemical Endocrinology
28 Cellular Homeostasis: Cell Growth and Cancer
29 Aging
SECTION 6 Fuels Nutrients and Minerals
30 Digestion and Absorption of Nutrients: The Gastrointestinal Tract
31 Glucose Homeostasis and Fuel Metabolism: Diabetes Mellitus
32 Nutrients and Diets
33 Lipoprotein Metabolism and Atherogenesis
SECTION 7 Specialized Tissues and Their Function
34 Role of Liver in Metabolism
35 Water and Electrolytes Homeostasis
36 The Lung and the Regulation of Hydrogen Ion Concentration (Acid–Base Balance)
37 Muscle: Energy Metabolism, Contraction, and Exercise
38 Bone Metabolism and Calcium Homeostasis
39 Neurochemistry
SECTION 8 Blood and Immunity. Clinical Biochemistry
40 Blood and Plasma Proteins
41 Hemostasis and Thrombosis
42 Oxidative Stress and Inflammation
43 The Immune Response: Innate and Adaptive Immunity
Appendix 1: Selected Clinical Laboratory Reference Ranges
Index
