World-renowned coverage of today’s pharmacology at your fingertips
Key Features
- Keeps you up-to-date with new information in this fast-changing field, including significantly revised coverage of CNS drugs, cognitive enhancers, anti-infectives, biologicals/biopharmaceuticals, lifestyle drugs, and more
- Includes access to unique features online, including more than 100 brand new chapter-specific multiple-choice questions and 6 new cases for immediate self-assessment
- Features a color-coded layout for faster navigation and cross-referencing
- Clarifies complex concepts with Key Points boxes, Clinical Uses boxes and full-color illustrations throughout
- Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices
Author Information
By James M. Ritter, DPhil FRCP FBPhS FMedSci, Emeritus Professor of Clinical Pharmacology, King’s College London, and Medical Research Director, Quintiles, London, UK; Rod J. Flower, PhD DSc FBPhS FMedSci FRS, Professor, Biochemical Pharmacology, The William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London , London, UK; Graeme Henderson, BSc PhD FBPhS FSB, Professor of Pharmacology, University of Bristol, Bristol, UK; Yoon Kong Loke, MB, BS, MRCP, MD, Senior Lecturer in Clinical Pharmacology, School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, UK; David MacEwan, PhD, FRSB, FBPhS, SFHEA, Professor of Molecular Pharmacology/Toxicology & Head of Department, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK and Humphrey P. Rang, MB BS MA DPhil Hon FBPharmacolS FMedSci FRS, Emeritus Professor of Pharmacology, University College London, London, UK
Section 1. General principles
1. What is pharmacology?
2. How drugs act: general principles
3. How drugs act: molecular aspects
4. How drugs act: cellular aspects excitation, contraction and secretion
5. Biopharmaceuticals and gene therapy
6. Cell proliferation, apoptosis, repair and regeneration
7. Cellular mechanisms: host defence
8. Method and measurement in pharmacology
9. Absorption and distribution of drugs
10. Drug metabolism and elimination
11. Pharmacokinetics
12. Individual Variation, Pharmacogenomics and Personalised Medicine
Section 2. Chemical Mediators
13. Chemical mediators and the autonomic nervous system
14. Cholinergic transmission
15. Noradrenergic transmission
16. 5-Hydroxytryptamine and the Pharmacology of Migraine
17. Purines
18. Local Hormones 1: Histamin and the Biologically Active Lipids.
19. Local Hormones 2: Peptides and Proteins
20. Cannabinoids
21. Nitric oxide and other gaseous mediators
Section 3. Drugs affecting major organ systems
22. The heart
23. The vascular system
24. Atherosclerosis and lipid metabolism
25. Haemostasis and thrombosis
26. Haemopoietic system
27. Anti-inflammatory and immunosuppressant drugs
28. Skin
29. Respiratory system
30. The Kidney and urinary system
31. The Gastrointestinal tract
32. The control of blood glucose and drug treatment of diabetes mellitus
33. Obesity
34. The Pituitary and the adrenal cortex
35. Thyroid
36. The reproductive system
37. Bone metabolism
Section 4. Nervous System
38. Chemical transmission and drug action in the nervous system
39. Amino acid transmitters
40. Other transmitters and modulators
41. Neurodegenerative diseases
42. General anaesthetic agents
43. Analgesic drugs
44. Local anaesthetics and other drugs affecting sodium channels
45. Anxiolytic and hypnotic drugs
46. Antiepileptic drugs
47. Antipsychotic drugs
48. Antidepressant drugs
49. CNS stimulants and psychotomimetic drugs
50. Drug addiction, dependence and abuse
Section 5. Drugs used for the treatment of infections and cancer
51. Basic principles of antimicrobial chemotherapy
52. Antibacterial drugs
53. Antiviral drugs
54. Antifungal drugs
55. Antiprotozoal drugs
56. Anthelmintic drugs
57. Anti-cancer drugs
Section 6. Special Topics
58. Harmful effects of drugs
59. Lifestyle drugs and drugs in sport
60. Drug discovery and development
"This book is well suited for a graduate-level pharmacology course for MS or PhD students or MD/PhD students." --Carol L Beck, PharmD, PhD (Thomas Jefferson University) Doody's Review Score: 90-4 Stars!
