Through six outstanding and award-winning editions, Ryan’s Retina has offered unsurpassed coverage of this complex subspecialty—everything from basic science through the latest research, therapeutics, technology, and surgical techniques. The fully revised 7th Edition, edited by Drs. SriniVas R. Sadda, Andrew P. Schachat, Charles P. Wilkinson, David R. Hinton, Peter Wiedemann, K. Bailey Freund, and David Sarraf, continues the tradition of excellence, balancing the latest scientific research and clinical correlations and covering everything you need to know on retinal diagnosis, treatment, development, structure, function, and pathophysiology. More than 300 global contributors share their knowledge and expertise to create the most comprehensive reference available on retina today.
Key Features
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Features sweeping content updates, including new insights into the fundamental pathogenic mechanisms of age-related macular degeneration, advances in imaging including OCT angiography and intraoperative OCT, new therapeutics for retinal vascular disease and AMD, novel immune-based therapies for uveitis, and the latest in instrumentation and techniques for vitreo-retinal surgery.
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Includes five new chapters covering Artificial Intelligence and Advanced Imaging Analysis, Pachychoroid Disease and Its Association with Polypoidal Choroidal Vasculopathy, Retinal Manifestations of Neurodegeneration, Microbiome and Retinal Disease, and OCT-Angiography.
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Includes more than 50 video clips (35 new to this edition) highlighting the latest surgical techniques, imaging guidance, and coverage of complications of vitreoretinal surgery. New videos cover Scleral Inlay for Recurrent Optic Nerve Pit Masculopathy, Trauma with Contact Lens, Recurrent Retinal Detachment due to PVR, Asteroid Hyalosis, and many more.
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Contains more than 2,000 high-quality images (700 new to this edition) including anatomical illustrations, clinical and surgical photographs, diagnostic imaging, decision trees, and graphs.
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Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Author Information
Edited by SriniVas R. Sadda, MD, President & Chief Scientific Officer, Doheney Eye Institute, Los Angeles, CA; Andrew P. Schachat, MD, Vice Chairman, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH, USA; Charles P. Wilkinson, MD, Chairman, Department of Ophthalmology, Greater Baltimore Medical Center; Professor, Department of Ophthalmology, John Hopkins University, Baltimore, MD, USA; David R. Hinton, MD, Gavin S. Herbert Professor of Retinal Research; Professor of Pathology and Ophthalmology, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Peter Wiedemann, MD, Head of the Department of Ophthalmology and Eye Hospital, Medical Faculty, University of Leipzig, Leipzig, Germany; K. Bailey Freund, MD, Clinical Professor of Ophthalmology, New York University School of Medicine; Vitreous Retina Macula Consultants of New York, New York City, NY and David Sarraf, MD, Clinical Professor of Ophthalmology, Stein Eye Institute
VOLUME 1
PART 1
Retinal Imaging and Diagnostics
1. Fluorescein Angiography: Basic Principles and Interpretation
2. Clinical Applications of Diagnostic Indocyanine Green Angiography
3. Optical Coherence Tomography
4. Optical Coherence Tomography Angiography (OCTA)
5. Autofluorescence Imaging
6. Widefield Imaging
7. Advanced Imaging Technologies
8. Artificial Intelligence and Advanced Imaging Analysis
9. Clinical Electrophysiology
10. Diagnostic Ophthalmic Ultrasound
11. Color Vision and Night Vision
12. Visual Acuity and Contrast Sensitivity
13. Visual Fields in Retinal Disease
PART 2
Basic Science and Translation to Therapy
SECTION 1 Anatomy and Physiology
14. The Development of the Retina
15. Function and Anatomy of the Mammalian Retina
16. Structure and Function of Rod and Cone Photoreceptors
17. Cell Biology of the Retinal Pigment Epithelium
18. Glial Cells of the Fovea
19. Retinal and Choroidal Vasculature: Retinal Oxygenation
20. Mechanisms of Normal Retinal Adhesion
21. Structure, Function, and Pathology of Bruch’s Membrane
22. Vitreous and Vitreoretinal Interface
SECTION 2 Basic Mechanisms of Injury in the Retina
23. Mechanisms of Oxidative Stress in Retinal Injury
24. Mechanisms of Endoplasmic Reticulum Stress in Retinal Disease
25. Cell Death, Apoptosis, and Autophagy in Retinal Injury
26. Inflammation and Immune Responses in Retinal Health and Disease
27. Basic Mechanisms of Pathologic Retinal and Choroidal Angiogenesis
28. Blood–Retinal Barrier, Immune Privilege, and Autoimmunity
29. Mechanisms of Diabetic Macular Edema and Therapeutic Approaches
30. Cellular Effects of Detachment and Reattachment on the Neural Retina and the Retinal Pigment Epithelium
31. Retinal Manifestations of Neurodegeneration: A Focus on Alzheimer Disease
SECTION 3 Genetics
32. Genetic Mechanisms of Retinal Disease
33. Mitochondrial Genetics of Retinal Disease
34. Epigenetic Mechanisms of Retinal Disease
35. Microbiome and Retinal Disease
SECTION 4 Translational Basic Science
36. Gene Therapy for Retinal Disease
37. Stem Cells and Cellular Therapy for Retinal Degenerative Diseases
38. Nanomedicine in Ophthalmology
39. Neuroprotection
40. Drug Delivery
41. Retinal Laser Therapy: Biophysical Basis and Applications
VOLUME 2
Medical Retina
SECTION 1 Retinal Degenerations and Dystrophies
42. Macular Dystrophies
43. Retinitis Pigmentosa and Allied Disorders
44. Abnormalities of Rod and Cone Function
45. Hereditary Vitreoretinal Degenerations
46. Hereditary Choroidal Dystrophies
SECTION 2 Retinal Vascular Disease
47. Diabetic Retinopathy: Etiologic Mechanisms and Genetics
48. Diabetes Mellitus
49. Nonproliferative Diabetic Retinopathy and Diabetic Macular Edema
50. Proliferative Diabetic Retinopathy
51. Telescreening for Diabetic Retinopathy
52. Hypertension
53. Retinal Artery and Capillary Occlusions
54. Acquired Retinal Macroaneurysms
55. Branch Retinal Vein Occlusion
56. Central Retinal Vein Occlusion
57. Macular Telangiectasia Type 2
58. Coats Disease
59. Hemoglobinopathies
60. Radiation Retinopathy
61. Ocular Ischemic Syndrome
62. Systemic Coagulopathy Syndromes
63. Pediatric Retinal Vascular Diseases
SECTION 3 Choroidal Vascular/Bruch’s Membrane Disease
64. Epidemiology and Risk Factors for Age-Related Macular Degeneration
65. Pathogenesis of Age-Related Macular Degeneration
66. Age-Related Macular Degeneration: Non-Neovascular Early AMD, Intermediate AMD, and Geographic Atrophy
67. Neovascular Age-Related Macular Degeneration
68. Pharmacotherapy of Age-Related Macular Degeneration
69. Pathologic Myopia
70. Angioid Streaks
71. Ocular Histoplasmosis
72. Pachychoroid Disease and Its Association With Polypoidal Choroidal Vasculopathy
73. Central Serous Chorioretinopathy
74. Uveal Effusion Syndrome and Hypotony Maculopathy
SECTION 4 Inflammatory Disease/Uveitis
Inflammation
75. Sympathetic Ophthalmia
76. Vogt–Koyanagi–Harada Disease
77. White Spot Syndromes and Related Diseases
78. Autoimmune Retinopathies
79. Sarcoidosis
80. Intermediate Uveitis
81. Rheumatic Disease
Infections
82. HIV-Associated Infections
83. Mycobacterial Infections
84. Eales Disease
85. Spirochetal Infections
86. Ocular Toxoplasmosis
87. Helminthic Disease
88. Endogenous Endophthalmitis: Bacterial and Fungal
89. Acute Retinal Necrosis Syndrome
90. Drug Toxicity of the Posterior Segment
91. Photic Retinal Injuries: Mechanisms, Hazards, and Prevention
92. Traumatic Chorioretinopathies
93. Retinal and Choroidal Disorders in Pregnancy (Pregnancy-Related Diseases)
94. Optic Disc Anomalies, Drusen, Pits, Hypoplasia, and Associated Retinal Pathology
95. Retina-Related Clinical Trials: A Resource Bibliography
VOLUME 3
PART 1 Surgical Retina
SECTION 1 The Pathophysiology of Retinal Detachment and Associated Problems
96. Pathogenetic Mechanisms of Retinal Detachment
97. Nonrhegmatogenous Retinal Detachment
98. Degenerative Retinoschisis
99. Pathogenesis of Proliferative Vitreoretinopathy
100. Pathophysiology of Ocular Trauma
SECTION 2 Retinal Reattachment: General Surgical Principles and Techniques
101. The Biomechanics of Scleral Buckles in the Treatment of Retinal Detachment
102. Techniques of Scleral Buckling
103. Principles and Techniques of Vitreoretinal Surgery
104. Intraoperative OCT Imaging
105. Primary Vitrectomy in Rhegmatogenous Retinal Detachment
106. Pneumatic Retinopexy
107. Special Adjuncts to Treatment
108. Optimal Procedures for Retinal Detachment Repair
109. Prevention of Retinal Detachment
SECTION 3 Complicated Forms of Retinal Detachment
110. Proliferative Vitreoretinopathy
111. Retinotomies and Retinectomies
112. Giant Retinal Tear
113. Surgery for Ocular Trauma: Principles and Techniques of Treatment
114. Surgery for Proliferative Diabetic Retinopathy
115. Management of Combined Inflammatory and Rhegmatogenous Retinal Detachment
116. High Myopia and the Vitreoretinal Complications
117. Surgical Management of Retinopathy of Prematurity
118. Surgery for Pediatric Vitreoretinal Disorders
SECTION 4 Vitreous Surgery for Macular Disorders
119. Epiretinal Membranes, Vitreoretinal Traction, Cystoid Macular Edema, and Submacular Hemorrhage
120. Macular Hole
121. Retinal Pigment Epithelium and Choroid Translocation in Patients With Age-Related Macular Degeneration
SECTION 5 Vitreous Surgery: Additional Considerations
122. Infectious Endophthalmitis
123. Diagnostic and Therapeutic Vitrectomy for Uveitis
124. Vitreous, Retinal, and Choroidal Biopsy
125. Transplantation Frontiers
126. Artificial Vision
127. Pharmacology During Surgery
128. Complications and Challenges in Vitreoretinal Surgery
PART 2
Tumors of the Retina, Choroid, and Vitreous
SECTION 1 Tumors of the Retina
129. Retinoblastoma
130. Cavernous Hemangioma
131. Hemangioblastoma of the Retina and von Hippel–Lindau Disease
132. Tuberous Sclerosis and the Eye
133. Phakomatoses
134. Retinal Metastases
135. Remote Effects of Cancer: Paraneoplastic Autoimmune Retinopathies
136. Optic Disc Melanocytoma
137. Congenital Hypertrophy of the Retinal Pigment Epithelium
138. Combined Hamartoma of the Retinal Pigment Epithelium and Retina
SECTION 2 Tumors of the Choroid
139. Choroidal Nevi
140. Epidemiology of Posterior Uveal Melanoma
141. Prognosis of Posterior Uveal Melanoma
142. Molecular Genetics of Choroidal Melanoma
143. Pathology of Choroidal Melanoma
144. Overview of Management of Posterior Uveal Melanoma
145. Enucleation for Choroidal Melanomas
146. Brachytherapy for Choroidal Melanoma
147. Charged-Particle Irradiation of Uveal Melanoma
148. Surgical Resection of Choroidal Melanoma
149. Laser Treatment of Choroidal Melanoma
150. Systemic Evaluation and Management of Patients With Metastatic Uveal Melanoma
151. Collaborative Ocular Melanoma Study
152. Choroidal Metastases
153. Choroidal Osteoma
154. Circumscribed Choroidal Hemangioma
SECTION 3 Hematologic and Miscellaneous Tumors
155. Miscellaneous Uveal Tumors
156. Leukemias and Lymphomas
157. Primary Vitreoretinal Lymphoma
Index
Doody's Core Titles® 2022
"...in this 7th edition, Ryan’s Retina makes it easier for residents and practicing ophthalmologists to work on patients and for basic researchers to familiarize themselves with retina. We can only thank the authors, the editor in chief, and the co-editors for their self-sacrificing work." -Graefe's Archive for Clinical and Experimental Ophthalmology (2022)
