Foreword .............................................................................................................................................................................................. v
Preface .................................................................................................................................................................................................. vii
Contributors ......................................................................................................................................................................................... ix
section i Introduction
Chapter 1 Sexual Health: Expanding Our Frame for Action ...................................................................................................... 3
Kevin A. Fenton
Chapter 2 Historical Aspects of Sexually Transmitted Infections............................................................................................... 10
James S. Bingham
section ii Epidemiology
— Christopher Fairley
Chapter 3 Global Epidemiology of Sexually Transmitted Infections ......................................................................................... 27
Ivonne Camaroni • Igor Toskin • Francis Ndowa • Antonio Carlos Gerbase
Chapter 4 Global Epidemiology of HIV Infection ........................................................................................................................ 44
Hammad Ali • Joanne Micallef • Basil Donovan
Chapter 5 Sexual Behavior and Sexually Transmitted Infections ................................................................................................ 57
Kaye Wellings
Chapter 6 Surveillance for Sexually Transmitted Infections and HIV ...................................................................................... 64
Rebecca Guy
Chapter 7 Epidemiological Interactions between HIV-1 and other STI: A Complex, Continuing Narrative ............... 74
Brian P. Mulhall
section iii Prevention and Control of Sexually Transmitted Infections and HIV
— Christopher Fairley
Chapter 8 Prevention Strategies for the Control of Sexually Transmitted Infections ........................................................... 91
Johannes van Dam
Chapter 9 Behavioral and Counseling Aspects of Sexually Transmitted Infections (Including HIV) .............................. 99
Michael W. Ross • Lena Nilsson Schönnesson
Chapter 10 Role of Behavioral Interventions in Prevention and Control of Sexually Transmitted Infections and HIV ......... 106
Devinder Mohan Th appa • Amiya Kumar Nath
Chapter 11 Condoms and Other Barrier Methods of STI and HIV Prevention ..................................................................... 117
Richard A. Crosby • Seth Noar • Sara Head • Elizabeth Webb
Chapter 12 Prevention of HIV and other Sexually Transmitted Infections: Male Circumcision ......................................... 134
Natasha L. Larke • Helen A. Weiss
Chapter 13 Microbicides for Prevention of Sexually Transmitted Infections ............................................................................ 139
G.P. Talwar • Kavita B. Garg
Chapter 14 Information and Communication Technologies to Support HIV and STI Care in Developing Countries .......... 150
Walter H. Curioso • Magaly Blas • Antonio Bernabe-Ortiz • Freddy Canchihuaman • Patricia J. Garcia
Chapter 15 Vaccines for Sexually Transmissible Infections ............................................................................................................. 161
Anna McNulty
Chapter 16 Vaccines for HIV ................................................................................................................................................................ 169
Stephen J. Kent • Amy Sexton • Ivan Stratov • Robert De Rose
Chapter 17 Partner Notifi cation for Sexually Transmitted Diseases ............................................................................................ 177
Matthew Hogben • Rachel Kachur • Molly Dowling • Lauren Green
section iv Public Health Aspects of STI Control
— Graham Neilsen
Chapter 18 Implementation of STI Programs ................................................................................................................................... 203
Gabriela Paz-Bailey • Jerry Owen Jacobson
Chapter 19 Integrating STI Prevention, Care, and Treatment with Other Sexual and Reproductive Health Services ........ 220
Kathryn Church
Chapter 20 Monitoring and Evaluating Sexually Transmitted Infection Control Programs .................................................. 234
Shanthi Noriega Minichiello • Timothy Ryan • Jerry Owen Jacobson • Gabriela Paz-Bailey
section v Basic and Laboratory Sciences
— Jonathan Ross
Chapter 21 Anatomy of the Male Genital Tract ............................................................................................................................... 249
Ashini Jayasuriya • Madhur Gupta
Chapter 22 Anatomy of the Female Genital Tract ............................................................................................................................ 257
Ashini Jayasuriya • Madhur Gupta
Chapter 23 Normal Genital Flora ........................................................................................................................................................ 264
Frances E. Keane
Chapter 24 History and Physical Examination ................................................................................................................................. 269
Keith Radcliff e
Chapter 25 Genital Mucosal Immunity Against Sexually Transmitted Infections ................................................................... 275
Satish K. Gupta • Manoj Modi • Nutan • Nachiket Shembekar • Shweta Malik • Suraj K. • Sanchita Chakravarty
Chapter 26 Laboratory Diagnosis of Sexually Transmitted Infections ........................................................................................ 287
Krishna Ray
Chapter 27 Rapid Tests for the Detection of Sexually Transmitted Infections ......................................................................... 321
Rosanna W. Peeling
section vi Viral Sexually Transmitted Infections
— Raj Patel
Chapter 28 Genital Herpes Simplex Infections ................................................................................................................................ 335
Raj Patel • Sangeetha Sundaram • Bhushan Kumar
Chapter 29 Anogenital Human Papillomavirus Infection: Natural History, Epidemiology, and Vaccination ................... 360
David Rowen • Paul Fox • Peter Goon
Chapter 30 Anogenital Warts, Intraepithelial Neoplasia, and their Clinical Management .................................................... 366
Paul Fox • David Rowen
Chapter 31 Molluscum Contagiosum ................................................................................................................................................. 374
Jyoti K. Dhar
Chapter 32 Hepatitis Viruses ................................................................................................................................................................. 380
Gary Brook • Yogesh Chawla
Chapter 33 Human Cytomegalovirus Infection ............................................................................................................................... 399
Krishna Ray • Manju Bala
Chapter 34 Epstein–Barr Virus Infections ......................................................................................................................................... 412
Raj Patel
Chapter 35 Kaposi Sarcoma Herpesvirus ........................................................................................................................................... 418
Rebecca Robey • Mark Bower
section vii Bacterial Sexually Transmitted Infections
— Jonathan Ross
Chapter 36 Infectious Syphilis............................................................................................................................................................... 429
Patrick French • Somesh Gupta • Bhushan Kumar
Chapter 37 Late Syphilis ......................................................................................................................................................................... 458
Ashish Sukthankar • Anne M. Rompalo
Chapter 38 Endemic Treponematoses ................................................................................................................................................. 467
C. Balachandran • Sathish Pai B
Chapter 39 Gonococcal Infections ....................................................................................................................................................... 473
Bellum Shiva Nagi Reddy • Sujay Khandpur • Sunil Sethi • Magnus Unemo
Chapter 40 Chlamydia Trachomatis Infections ................................................................................................................................ 494
Nicola Steedman
Chapter 41 Lymphogranuloma Venereum .......................................................................................................................................... 506
Henry JC de Vries • Bellum Shiva Nagi Reddy • Sujay Khandpur
Chapter 42 Chancroid ............................................................................................................................................................................. 522
Soni Nanda • B. Viswanath Reddy • Bellum Shiva Nagi Reddy
Chapter 43 Donovanosis......................................................................................................................................................................... 533
Nigel O’Farrell
Chapter 44 Bacterial Vaginosis .............................................................................................................................................................. 542
Phillip Hay • Verapol Chandeying
Chapter 45 Pelvic Infl ammatory Disease ............................................................................................................................................ 557
Jonathan D.C. Ross
Chapter 46 Genital Mycoplasmas ......................................................................................................................................................... 569
Jørgen Skov Jensen
Chapter 47 Sexually Transmitted Anorectal Infections and Enteric Bacterial Infections ....................................................... 578
Jason C.B. Goh • S. Joseph Winceslaus
section viii Fungi, Protozoa, and Arthropods
— Charlotte A. Gaydos
Chapter 48 Genital Candidal Infections............................................................................................................................................. 591
P. Janet Say
Chapter 49 Trichomonas Vaginalis Infections ................................................................................................................................... 602
Barbara Van Der Pol
Chapter 50 Intestinal Protozoa ............................................................................................................................................................. 610
Lara Stabinski • Mahesh Sharma • Vineet Ahuja
Chapter 51 Scabies and Pediculosis Pubis .......................................................................................................................................... 621
Peter Leone • T.V. Gopalkrishnan • V. Usha
section ix Sexually Transmitted Infection Syndromes and their Management
— Antonio Carlos Gerbase
Chapter 52 Th e Syndromic Approach for the Management of STIs: An Overview ................................................................ 633
Ahmed S. Latif
Chapter 53 Genital Ulcer-Adenopathy Syndrome ............................................................................................................................ 643
Francis Ndowa • Fatim Cham • Sibongile Dludlu
Chapter 54 Urethral Discharge ............................................................................................................................................................. 652
Francis Ndowa • Sibongile Dludlu
Chapter 55 Epididymitis and Epididymo-orchitis ............................................................................................................................ 658
Francis Ndowa • Sibongile Dludlu
Chapter 56 Abnormal Vaginal Discharge: Syndromic Management ............................................................................................ 662
Verapol Chandeying • Nutthaporn Chandeying
Chapter 57 Syndromic Management of Lower Abdominal Pain in Women ............................................................................. 679
Ahmed S. Latif
Chapter 58 Inguinal and Femoral Buboes .......................................................................................................................................... 683
Somesh Gupta • Bhushan Kumar
section x Genital Dermatology and Genital Pain Syndrome
— Mikhail Gomberg
Chapter 59 Balanitis and Balanoposthitis .......................................................................................................................................... 691
Michael Waugh • Sunil Dogra
Chapter 60 Non-venereal Penile Dermatoses .................................................................................................................................... 703
Christopher B. Bunker
Chapter 61 Vulvar Dermatoses .............................................................................................................................................................. 728
Mohammed Sharaf • Jennifer Gloeckner Powers • Andrew T. Goldstein • Nellie Konnikov
Chapter 62 Vulvar Vestibulitis Syndrome ........................................................................................................................................... 744
Jorma Paavonen • Leila Unkila-Kallio • Päivi Tommola
Chapter 63 Male Genital Pain Syndromes ......................................................................................................................................... 747
G.A. Luzzi • D. Mandal
section xi Sexually Transmitted Syndromes and Other Organ Systems
— Jonathan Ross
Chapter 64 Ocular Manifestations of Sexually Transmitted Infections ....................................................................................... 759
Jyotirmay Biswas • Parthopratim Dutta Majumder • Sudharshan S.
Chapter 65 Arthritis Associated with Sexually Transmitted Infections ....................................................................................... 768
Pradeep Bambery
section xii HIV Infection and AIDS
Part A HIV Infection: Biology, Laboratory Science, Clinical Pharmacology, and Therapeutics
— Brian P. Mulhall
Chapter 66 Human Immunodefi ciency Virus: Biology and Natural History of Infection ..................................................... 779
Sunil K. Arora • R.S. Paranjape • Srikanth Tripathy • Ajay Wanchu
Chapter 67 HIV Diagnosis .................................................................................................................................................................... 795
Jessica Markby • Claire Ryan
Chapter 68 Pharmacology of Antiretroviral Drugs ........................................................................................................................... 805
Tara McGinty • Patrick W.G. Mallon
Chapter 69 Surrogate Markers of Antiretroviral Effi cacy ............................................................................................................... 826
Julian H. Elliott • Johan Van Griensven • James McMahon • Lutgarde Lynen
Chapter 70 First Decade of ARV in Africa: Overcoming Barriers to Providing ARV Th erapy in Resource-Limited Settings .. 831
Nathan Ford • Alexandra Calmy
Chapter 71 Antiretroviral Drugs for HIV Prevention ..................................................................................................................... 836
Hubert Maruszak • Don Smith • Brian P. Mulhall
Part B Clinical Presentations
— Janak K. Maniar
Chapter 72 Acute HIV Infection ......................................................................................................................................................... 843
Sabine Kinloch • Steven J. Reynold • Robert C. Bollinger
Chapter 73 Opportunistic Infections .................................................................................................................................................. 849
Hiten Th aker • A.V. Balaji
Chapter 74 Mucocutaneous Manifestations of HIV ........................................................................................................................ 871
Yogesh Marfatia • Ranjan Rawal • Keyur Shah • Smriti Naswa
Chapter 75 Pulmonary Manifestations of HIV Disease .................................................................................................................. 894
Resham Vasani • Ratnakar Kamath • J.K. Maniar
Chapter 76 Neurological Manifestations of HIV .............................................................................................................................. 910
Arun B. Shah • Ramshekhar Menon
Chapter 77 Gastrointestinal Manifestations of HIV Infection and AIDS.................................................................................. 927
Saroj K. Sinha • Rakesh Kochhar
Chapter 78 Renal Manifestations of HIV Infection and AIDS .................................................................................................... 951
Frank Post • Rushi Deshpande
Chapter 79 HIV and Endocrine Manifestations ............................................................................................................................... 960
Shiva Prakash • Ravinder Goswami
Chapter 80 AIDS Associated Malignancies and Th eir Treatment ................................................................................................ 966
Mark Bower • David Shackleton • Justin Stebbing
Chapter 81 Rheumatic Manifestations of HIV and AIDS ............................................................................................................. 980
Vikram A. Londhey • Milind Y. Nadkar
Chapter 82 Cardiac Involvement in HIV Infection/AIDS ............................................................................................................ 988
Yash Paul Sharma • Rakesh Raman Patyar
Chapter 83 Ocular Manifestations of HIV Infection and AIDS .................................................................................................. 993
Jyotirmay Biswas • Kaushal Bhavsar • Sudharshan S.
Chapter 84 Sexually Transmitted Infections in HIV-Infected Patients ....................................................................................... 1003
V. Harindra
Part C Human Immunodefi ciency Virus Infection in Special Groups
— Brian P. Mulhall
Chapter 85 Human Immunodefi ciency Virus Infection in Women ............................................................................................. 1016
Noreen A. Hynes • Jean Anderson • Adriana Andrade
Chapter 86 HIV in Children ................................................................................................................................................................. 1025
J. Lucey • C. Foster • T. Puthanakit • J. Ziegler • P. Palasanthiran
Chapter 87 HIV Infection in Homosexual Men .............................................................................................................................. 1037
Mark Bloch • Brian P. Mulhall • Charles Farthing • Richard Hillman
Chapter 88 HIV in Blood and Blood Product Recipients .............................................................................................................. 1050
Roger J. Garsia
Chapter 89 HIV in Injection and Other Drug Users ..................................................................................................................... 1061
Jaimie P. Meyer • Frederick L. Altice
section xiii Sexually Transmitted Infections in Special Groups of Populations
— Mikhail Gomberg
Chapter 90 Sexually Transmitted Infections and Pregnancy .......................................................................................................... 1081
Sarla Malhotra
Chapter 91 Sexually Transmitted Infections in Neonates and Infants ......................................................................................... 1095
P. Janet Say • Ravi Chandra Sharma
Chapter 92 Congenital Syphilis ............................................................................................................................................................ 1103
Carlos Velásquez • Cristina Guerra-Giraldez • Lorenzo Giacani • Arturo Centurion-Lara • Patricia J. García
Chapter 93 Sexually Transmitted Infections and Infertility ............................................................................................................ 1121
V.G. Padubidri • Sarla Malhotra
Chapter 94 Aging, Sexual Behavior, and HIV/STI Risk ................................................................................................................ 1129
Massimo Giuliani
Chapter 95 Sexually Transmitted Infections in the Female Sex Worker Community ............................................................. 1136
Samarjit Jana • Geeta Sethi • D. Mandal
Chapter 96 Sexually Transmitted Infections Associated with Sexual Assault ............................................................................ 1146
P. Janet Say
Chapter 97 Sexual Health of Migrant Populations ........................................................................................................................... 1153
Andy J. Williams • Beng T. Goh
section xiv Human Sexuality, Sexual Orientation, and Special Issues
— Darren Russell
Chapter 98 Human Sexuality ................................................................................................................................................................ 1165
D. Narayana Reddy
Chapter 99 Homosexuality, Bisexuality, and Sexual Orientation .................................................................................................. 1174
David Bradford
Chapter 100 Sexually Transmitted Infections among Women who have Sex with Women ..................................................... 1179
Jeanne Marrazzo • Devika Singh
Chapter 101 Sexually Transmitted Infections in Transgender ......................................................................................................... 1188
Darren Russell
Chapter 102 Sexual Abuse in Children ................................................................................................................................................. 1192
Savita Malhotra • Nitin Gupta • Anindya Banerjee
Chapter 103 Male Sexual Dysfunction .................................................................................................................................................. 1203
Phillip Kell
Chapter 104 Women’s Sexual Dysfunction .......................................................................................................................................... 1210
Verapol Chandeying
Chapter 105 Sexuality Education for Young People ........................................................................................................................... 1221
Anne Mitchell • Jenny Walsh
Chapter 106 Dhat Syndrome: A Culture-Bound Sex Related Disorder in Indian Subcontinent ........................................... 1225
Ajit Avasthi • Sandeep Grover • Om Prakash Jhirwal
section xv Miscellaneous
— Charlotte A. Gaydos
Chapter 107 Clinical Services for Sexually Transmitted Infections and HIV .............................................................................. 1231
Joyce Jones • Emily Erbelding
Chapter 108 Medicolegal Aspects of Sexually Transmitted Infections and Sexual Assault ...................................................... 1236
Margaret R. Hammerschlag
Chapter 109 Sexually Transmitted Infections: Screening and Diagnostic Practices ................................................................... 1242
Charlotte A. Gaydos
Chapter 110 Sexually Transmitted Infections Related Genital Neoplasias ................................................................................... 1251
Suzanne M. Garland
Chapter 111 HIV, Sexually Transmitted Infections, and Human Rights ...................................................................................... 1259
Chris Beyrer • Stefan D. Baral
Chapter 112 Animal Models of Sexually Transmitted Infections .................................................................................................... 1269
Roger G. Rank • Richard B. Pyles
section xvi Guidelines for the Management of Sexually Transmitted Diseases and HIV
— Basil Donovan
Chapter 113 Guidelines for the Management of Sexually Transmitted Infections ..................................................................... 1299
Ahmed S. Latif • Charles Mutandwa
Chapter 114 Guidelines for the Treatment of HIV in Industrialized and Middle Income Countries—
Adults, Adolescents, and Pediatric ................................................................................................................................. 1310
Saliya Hewagama • Jennifer Hoy
Chapter 115 Guidelines for the Treatment of HIV and AIDS in Resource-Limited Countries ............................................ 1328
Chris Duncombe • Deepti Suri
Chapter 116 Guidelines for Prevention of Perinatal HIV Infection ............................................................................................... 1345
Surjit Singh • Deepti Suri
Chapter 117 Guidelines for the Management of HIV-Associated Opportunistic Infections ................................................... 1358
Phillip J. Read
Index ......................................................................................................................................... 1369